Cardiac cachexia and muscle wasting: definition, physiopathology, and clinical consequences
نویسندگان
چکیده
منابع مشابه
Cardiac muscle wasting in individuals with cancer cachexia
AIMS Cachexia is a severe complication of cancer that adversely affects the course of the disease and is associated with high rates of mortality. Patients with cancer manifest symptoms, such as fatigue, shortness of breath, and impaired exercise tolerance, which are clinical signs of chronic heart failure. The aim of this study was to evaluate cardiac muscle wasting in cancer individuals. MET...
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Almost half of cancer patients experience cachexia syndrome. Cachexic patients are at risk of increased side effects of chemotherapy, reduced tolerance to chemotherapy drugs, longer duration of treatment period, and decreased quality of life. Cancer cachexia is a multifactorial syndrome. Micro ribonucleic acid (miRNA), a “non-coding RNA”, is considered to be a risk factor of cachexia and muscle...
متن کاملCancer cachexia-anorexia syndrome and skeletal muscle wasting
Background. Cachexia-anorexia syndrome is a common and important indicator of cancer. It occurs in 30% to 80% of cancer patients. Cachexia means “bad condition” and may be present in the early stages of tumor growth, before any signs of malignancy. Cancer cachexia is a syndrome of progressive body wasting, characterized by loss of adipose tissue and skeletal muscle mass. In most cancer patients...
متن کاملMyostatin: Regulator of muscle wasting in heart failure and treatment target for cardiac cachexia.
Myostatin, also known as growth differentiation factor-8 (GDF-8), is a member of the transforming growth factorsuperfamily and was identified in 1997.1 In humans, myostatin is expressed almost exclusively in skeletal muscle and is essential for normal regulation of muscle mass through its actions as a negative regulator of muscle bulk.2 Gene disruption, either natural or by targeted mutation, l...
متن کاملRegulator of Muscle Wasting in Heart Failure and Treatment Target for Cardiac Cachexia
Myostatin, also known as growth differentiation factor-8 (GDF-8), is a member of the transforming growth factorsuperfamily and was identified in 1997.1 In humans, myostatin is expressed almost exclusively in skeletal muscle and is essential for normal regulation of muscle mass through its actions as a negative regulator of muscle bulk.2 Gene disruption, either natural or by targeted mutation, l...
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ژورنال
عنوان ژورنال: Research Reports in Clinical Cardiology
سال: 2014
ISSN: 1179-8475
DOI: 10.2147/rrcc.s41513